Micky van de Ven Double Ends Everton's Unbeaten Streak at New Stadium
The Dutch defender emerged as the first defender to score two goals in a English top-flight match for Tottenham since the Belgian defender in spring 2013.
Match summary
The Spurs defender nods home twice in opening period
The home side's defender has equalizer ruled after VAR review
Senegalese midfielder nets third in 89th minute
The defeat is the Merseyside club's first at Hill Dickinson Stadium
The Tottenham defender found the net on two occasions as Tottenham extended their unbeaten run on the road in the Premier League and handed the Toffees their initial loss at Hill Dickinson Stadium.
The Toffees were unbeaten in their last five matches at their recently opened stadium at the dockside location, having departed their historic home behind after 133 years at the conclusion of the previous campaign.
But Tottenham's leader the Dutchman pounced on two occasions from corners in the opening 45 minutes to place their impressive record at jeopardy, and they were failed to turn it around before the midfielder - set up by former Toffees attacker Richarlison - headed home a third to seal the victory.
Jake O'Brien believed he had equalized the scores a short while after the defender's opener, directing a bullet header past the Spurs keeper from an Everton corner.
Beto, meanwhile, missed a number of opportunities, while the Italian goalkeeper made a series of excellent saves to ensure Tottenham went five matches on the road without defeat in the English top flight.
But the VAR intervened, instructing Craig Pawson to review the score on the pitchside monitor and the referee ruled that the winger and the attacker were in an illegal position and had impeded with the Tottenham goalkeeper.
This victory moves the manager's side up to third in the Premier League, five points off local foes and leaders Arsenal.
Everton stay 14th and sit six points clear of the relegation zone.
Spurs breakdown: Van de Ven fulfils role at both ends of pitch
After a uninspiring midweek performance in the European competition against Monaco, where they mustered a only two shots on goal, the manager chose Randal Kolo Muani up front instead of ex-Everton forward the Brazilian.
The summer signing was unable to make much of an impact before being replaced for the substitute after 60 minutes on the pitch, but it emerged he wasn't needed in the end.
Centre-back the Dutchman transformed into an attacking force to be feared.
Tottenham's first goal came from a well-worked set-piece play, with the midfielder directing the ball toward the six-yard box for an unmarked Van de Ven to score.
And Ven de Ven - stepping up as captain in the Argentine's unavailability - notched his second in first-half stoppage time as he rose above Jordan Pickford to nod in.
Van de Ven was equally impressive in defence, partnering effectively with his defensive colleague as the duo dealt excellently with the numerous deliveries sent their way by the opposition.
Toffees breakdown: Everton lacking striker's instinct
The club's new home had been a happy hunting ground, but it appears the novelty may have worn off somewhat and fans headed to the gates after Sarr's third for Spurs.
The end in the team's unbeaten home run won't be a massive concern for the manager, but their striker situation will be.
The forward and Thierno Barry - the Toffees' pair of recognised strikers - had scored only one league goal between them before the weekend's match.
And they were failed to add to that miserable tally on a damp and dreary night on in Liverpool.
The striker's performance was summed up when he chose to bicycle-kick a golden opportunity from near the goal, despite having room and time to readjust for a simpler shot that would have tested Vicario.
The substitute, too, failed to make an impact after replacing Beto in the 65th minute.
It wasn't for a shortage of chance. Most of the home side's offensive moves came through Grealish and Ndiaye, who tirelessly delivered threatening crosses into the Spurs box.
Upcoming fixtures for these two sides?
The Toffees: Moyes' men travel to Sunderland in the top flight on Monday, 3 November at 8 PM.
Spurs: The London club go to St James' Park on late October for their next round League Cup tie against the Magpies.